Unusual presentation of malignant phyllodes tumor in a young female: (Case report and review of literatures) malignant phyliodes tumor in adolesent.

Main Article Content

Hind Al-hashemi
Saad Abdulbaqi Alomar
sawsan Al-Haroon


, phyllodes tumor, , Adolesence, malignant tumor, brest tumors



Phyllodes tumor (PT) of the breast is rare in adolescent females, particularly malignant ones. It usually occurs in middle aged and older women. Malignant phyllodes (MP) do have a recurrence and a metastatic potential, unlike benign or borderline PT. We present the case of a 16-years old female presenting with a 6- month history of a progressive enlarged left breast mass. Tumor was excised as a mass of 7 cm in maximum diameter and sent for histopathological examination. The Histopathology revealed features of malignant phyllodes tumor that were confirmed by immunohistochemistry.

Abstract 38 | Full text PDF Downloads 36


1- Chen, Wei-Hsin . A rare presentation of malignant phyllodes tumor with bloody nipple discharge—report of a case. Gland Surgery 2017; 6(4), 412–416.
2- Sheppard, S., Shah, R., Madrigrano, A., & Kopkash, K. Malignant Phyllodes: A Presentation of Two Patients with a Rare Disease. The American Surgeon 2017; 83(12), 478-479.‏
3- Mills, S. E., Greenson, J. K., Hornick, J. L., Longacre, T. A., & Reuter, V. E. Sternberg's diagnostic surgical pathology, 6th ed. Lippincott Williams & Wilkins:1154-1159;2015.‏
4- Martino, A., Zamparelli, M., Santinelli, A., Cobellis, G., Rossi, L., & Amici, G. Unusual clinical presentation of a rare case of phyllodes tumor of the breast in an adolescent girl. Journal of pediatric surgery 2001; 36(6), 941-943.‏.
5- Collin, Y., Chagnon, F., Mongeau, C. J., Gonzalez-Amaya, G. L., & Sideris, L. Adrenal metastasis of a phyllodes tumor of the breast: case report and review of the literature. International Journal of Surgery Case Reports 2013; 4(8), 687-689.‏
6- Joshua J.X. Li. Fibroepithelial tumors, Phyllodes tumor [online]. Available from: https://www.pathologyoutlines.com/topic/breastphyllodesgeneral.html. Accessed date in 2/5/2022 at 6 p.m.
7- Fede, Â. B. D. S., Pereira Souza, R., Doi, M., De Brot, M., Aparecida Bueno de Toledo Osorio, C., Rocha Melo Gondim, G., …& Moraes Sanches, S. Malignant phyllodes tumor of the breast: a practice review. Clinics and practice 2021; 11(2), 205-215.‏
8- Feig, B. W., Berger, D. H., & Fuhrman, G. M. (Eds.). The MD Anderson surgical oncology handbook, 4th ed. Lippincott Williams & Wilkins: 57;2006.
9- Schnitt, S. J., & Collins, L. C. Biopsy interpretation of the breast, 3rd ed. Lippincott Williams & Wilkins, Philadelphia: 166-178;2009.
10- Gibbs Jr, B. F., Roe, R. D., & Thomas, D. F. Malignant cystosarcoma phyllodes in a pre-pubertal female. Annals of Surgery 1968; 167(2), 229-231.‏
11- Obafunwa, JO & Nwana, E. J. C. Malignant cystosarcoma phyllodes: report of two cases. Central African journal of medicine 1989; 35(10), 510-513.‏
12- Leveque, J., Meunier, B., Wattier, E., Burtin, F., Grall, J. Y., & Kerisit, J. Malignant cystosarcomas phyllodes of the breast in adolescent females. European Journal of Obstetrics & Gynecology and Reproductive Biology 1994; 54(3), 197-203.‏
13- Olugbenga, S., Isichei, M., & Isichei, C. Malignant Phyllodes Tumour in a Non-Governmental Health Centre (Faith Alive Foundation) in Jos, Plateau State North Central Nigeria. A Case Report and Review of Literature. Jos Journal of Medicine 2011; 5(2), 50-53.‏
14- Mills, A. M., & Showalter, S. L. Malignant Phyllodes Tumor of the Breast: A Case Study. Clinical Journal of Oncology Nursing 2014; 18(5), 595–597.
15- Athamnah, M. N., Abuelaish, O. M., & Rabai, N. A. Multifocal intra-parenchymal and sub-pectoral malignant phyllodes tumor in young female, rare and unusual presentation: a case report. International Journal of Surgery Case Reports 2020; 71, 280-284.‏
16- Makar, G. S., Makar, M., Ghobrial, J., Bush, K., Gruner, R. A., & Holdbrook, T. Malignant phyllodes tumor in an adolescent female: A rare case report and review of the literature. Case Reports in Oncological Medicine 2020; 1-7.‏
17- Saad, M. K., El Hajj, I., & Saikaly, E. Large Malignant Phyllodes Tumor of the Breast: Case Report of a Young Female and Review of Literature. Archives of Breast Cancer 2020; 137-146.‏
18- Muhammad, I. M., Musa, A. Gombe, A. A. A rare case of giant malignant phyllodes tumour and long term survival. Kanem Journal of Medical Sciences 2021; 15(2), 132 – 135.
19- Shaukat, U., Rehman, U., Younis, M. N., & Shahid, A. Malignant Phyllodes Breast Tumor: A Rare Case of Metastasis in Skeletal Muscle Detected on 18-Fluorodeoxyglucose Positron