The novel use of convalescent plasma in patients with Covid-19 in Basra governorate: Case series review The novel use of convalescent plasma in patients with Covid-19 in Basra governorate: Case series review
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Keywords
convalescent plasma, COVID-19, SARS CoV-2, apheresis, plasma exchange, plasma donation
Abstract
Background: The idea of convalescent plasma usage is to give passive immunity to the patients, so their immune system has a good chance of combating the virus. This study will review 6 cases of eligible Covid-19 patients that had been treated with convalescent plasma therapy in Basra Covid-19 quarantine.
Objectives: to demonstrate efficacy and safety of convalescent plasma in the patient series that had been enrolled.
Method: this study has pioneered a new method to collect up to 3,000 mL of convalescent plasma in one session by an off-label use of Spectra Optia Apheresis systems/TerumoBCT /Exchange set. In this study 250 mL of the collected convalescent plasma had been given to each of the 6 patients, from one donor. Response in SpO2, dyspnea, and tachypnoea was observed.
Any reaction to plasma also has been monitored .
Result: Our case series have demonstrated both safety and effectiveness of convalescent plasma. This study was successful in reaching our primary and secondary outcomes in all 6 patients (improvement in SpO2 and symptoms). With negligible difference in time of post transfusion response.
Conclusion: convalescent plasma is apperantly safe and effective. In this study 250 mL of convalescent plasma has been given to each of the 6 patients, from one donor, using Therapeutic Plasma Exchange (TPE) protocol by Spectra Optia Apheresis system/TerumoBCT.
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