A Higher Prevalence of Diabetes Mellitus Among Patient with Nonarteritic Ischemic Optic Neuropathy A Higher Prevalence of Diabetes Mellitus Among Patient with Nonarteritic Ischemic Optic Neuropathy

Main Article Content

Ahmed A. Almaliky
Hani M. Mansoor
Majid H. Alabbood

Keywords

Optic Neuropathy, Diabetes Mellitus, Hypertension, basrah

Abstract

Background: The association of diabetes mellitus, nighttime blood pressure dipping and nonarteritic ischemic optic neuropathy is inconclusive. There has been no study to test this association among Arab Patients.


Objectives: This study aims to test the association between diabetes mellitus, nighttime blood pressure dipping and nonarteritic ischemic optic neuropathy among cohort of patients from Basrah, Southern Iraq.


Methods: This was a cross-sectional study on patients with nonarteritic ischemic optic neuropathy conducted at the ophthalmology clinic at Faiha Teaching Hospital in 2018. Patients with nonarteritic ischemic optic neuropathy were screened for diabetes mellitus. Ambulatory blood pressure monitor was attached to some of the participants for 24 hours. Nighttime blood pressure dipping was classified into 4 categories:  normal, blunted, severe and reverse.


Results: A total of 74 patients with nonarteritic ischemic optic neuropathy were included. Females constituted 64.9 % of the cases. Forty patients (53.3%) were found to have diabetes mellitus. While 41 participants (55.5 %) were hypertensive. Nocturnal dipping of blood pressure was measured in 38 patients. Only 6 (15.7%) of them had severe dipping.


Conclusions: There may be an association between diabetes mellitus but not nighttime blood pressure dipping with nonarteritic ischemic optic neuropathy.


 


 

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References

1. Chen T, Song D, Shan G, Wang K, Wang Y, Ma J, et al. The association between diabetes mellitus and nonarteritic anterior ischemic optic neuropathy: a systematic review and meta-analysis. PLoS One. 2013;8(9):e76653.
2. Miller NR, Arnold A. Current concepts in the diagnosis, pathogenesis and management of nonarteritic anterior ischaemic optic neuropathy. Eye. 2015;29(1):65.
3. Falavarjani KG, Sanjari MS, Modarres M, Aghamohammadi F. Clinical profile of patients with nonarteritic anterior ischemic optic neuropathy presented to a referral center from 2003 to 2008. Arch Iran Med. 2009;12(5).
4. Giambene B, Sodi A, Sofi F, Marcucci R, Fedi S, Abbate R, et al. Evaluation of traditional and emerging cardiovascular risk factors in patients with non-arteritic anterior ischemic optic neuropathy: a case-control study. Albrecht Von Graefes Arch Klin Exp Ophthalmol. 2009;247(5):693-7.
5. Hayreh SS, Joos KM, Podhajsky PA, Long CR. Systemic diseases associated with nonarteritic anterior ischemic optic neuropathy. Am J Ophthalmol. 1994;118(6):766-80.
6. Lee MS, Grossman D, Arnold AC, Sloan FA. Incidence of nonarteritic anterior ischemic optic neuropathy: increased risk among diabetic patients. Ophthalmol. 2011;118(5):959-63.
7. Salomon O, Huna-Baron R, Kurtz S, Steinberg DM, Moisseiev J, Rosenberg N, et al. Analysis of prothrombotic and vascular risk factors in patients with nonarteritic anterior ischemic optic neuropathy. Ophthalmol. 1999;106(4):739-42.
8. Bulboacă A, Nicula C. Arterial hypotension-risk factor in nonarteritic anterior ischemic optic neuropathy. Oftalmol (Bucharest, Romania: 1990). 2002;53(2):52-5.
9. Hayreh SS, Zimmerman MB, Podhajsky P, Alward WL. Nocturnal arterial hypotension and its role in optic nerve head and ocular ischemic disorders. Am J Ophthalmol. 1994;117(5):603-24.
10. Association AD. Diagnosis and classification of diabetes mellitus. Diabetes care. 2010;33(Supplement 1):S62-S9.
11. Li J, McGwin G, Vaphiades MS, Owsley C. Non-arteritic anterior ischaemic optic neuropathy and presumed sleep apnoea syndrome screened by the Sleep Apnea scale of the Sleep Disorders Questionnaire (SA-SDQ). Br J Ophthalmol. 2007;91(11):1524-7.
12. Felekis T, Kolaitis NI, Kitsos G, Vartholomatos G, Bourantas KL, Asproudis I. Thrombophilic risk factors in the pathogenesis of non-arteritic anterior ischemic optic neuropathy patients. Albrecht Von Graefes Arch Klin Exp Ophthalmol. 2010;248(6):877-84.
13. Osusky R, Rohr P, Schötzau A, Flammer J. Nocturnal dip in the optic nerve head perfusion. Jpn J Ophthalmol. 2000;44(2):128-31.
14. Bowe A, Grünig M, Schubert J, Demir M, Hoffmann V, Kütting F, et al. Circadian variation in arterial blood pressure and glaucomatous optic neuropathy—a systematic review and meta-analysis. Am J Hypertens. 2015;28(9):1077-82.
15. Reddy D, Rani PK, Jalali S, Rao HL. A Study of Prevalence and Risk Factors of Diabetic Retinopathy in Patients with Non-Arteritic Anterior Ischemic Optic Neuropathy (NA-AION). Semin Ophthalmol. 2015;30(2):101-4.
16. James PA, Oparil S, Carter BL, Cushman WC, Dennison-Himmelfarb C, Handler J, et al. 2014 evidence-based guideline for the management of high blood pressure in adults: report from the panel members appointed to the Eighth Joint National Committee (JNC 8). Jama. 2014;311(5):507-20.
17. Kario K, Schwartz JE, Pickering TG. Changes of nocturnal blood pressure dipping status in hypertensives by nighttime dosing of α-adrenergic blocker, doxazosin: results from the HALT Study. Hypertension. 2000;35(3):787-94.
18. Jacobson DM, Vierkant RA, Belongia EA. Nonarteritic anterior ischemic optic neuropathy: a case-control study of potential risk factors. Arch Ophthalmol. 1997;115(11):1403-7.
19. Arnold AC. Pathogenesis of nonarteritic anterior ischemic optic neuropathy. J Neuroophthalmol. 2003;23(2):157-63.
20. Deramo VA, Sergott RC, Augsburger JJ, Foroozan R, Savino PJ, Leone A. Ischemic optic neuropathy as the first manifestation of elevated cholesterol levels in young patients. Ophthalmol. 2003;110(5):1041-6.
21. Ciulla TA, Amador AG, Zinman B. Diabetic retinopathy and diabetic macular edema: pathophysiology, screening, and novel therapies. Diabetes care. 2003;26(9):2653-64.
22. Landau K, Winterkorn JM, Mailloux LU, Vetter W, Napolitano B. 24-hour blood pressure monitoring in patients with anterior ischemic optic neuropathy. Arch Ophthalmol. 1996;114(5):570-5.
23. Johnson LN, Arnold AC. Incidence of nonarteritic and arteritic anterior ischemic optic neuropathy. Population-based study in the state of Missouri and Los Angeles County, California. J Neuroophthalmol. 1994;14(1):38-44.
24. Guyer DR, Miller NR, Auer CL, Fine SL. The risk of cerebrovascular and cardiovascular disease in patients with anterior ischemic optic neuropathy. Arch Ophthalmol. 1985;103(8):1136-42.
25. Repka MX, Savino PJ, Schatz NJ, Sergott RC. Clinical profile and long-term implications of anterior ischemic optic neuropathy. Am J Ophthalmol. 1983;96(4):478-83.
26. Talks S, Chong N, Gibson J, Dodson P. Fibrinogen, cholesterol and smoking as risk factors for non-arteritic anterior ischaemic optic neuropathy. Eye. 1995;9(1):85.

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